Welcome to the Bioinfotropes Wiki
Bioinfotropes is a collection of patterns, paradigms, and concepts for guiding new discoveries in systems biology and building better descriptions of familiar systems. Common themes in the evolutionary behavior of systems biology, in the observed behaviors of various bioinformatics tools and approaches, in rationales for rule-based annotation and hypothesis generation, and in emerging descriptive frameworks from the bioinformatics literature are discussed here. The coinage "Bioinfotropes" pays tribute to TV Tropes, a cataloguing of literary devices and conventions that writers can predict will resonate with the expectations and experience of their audiences.
Listed Bioinfotropes
Anna Karenina principle for microbiomes
edge piece for system reconstruction
fitness factors a.k.a. lysogenic conversion genes, "morons"
Genome Properties and SEED Subsystems
non-orthologous gene displacement
phylogenetic footprinting (contribution invited)
uniform functional organization
upstream and auxiliary components
History and Support
Bioinfotropes was founded in November 2010 by Daniel Haft, an Assistant Professor at the J. Craig Venter Institute, as a means to create vocabularies through which experts in bioinformatics can more easily communicate their findings and methods. It is also intended to serve as resource that will enhance community development of rule-based annotation. This project abstracts a number of advances in bioinformatics in which the logic of the approach exploits special characteristics of the class of system under study. Bioinfotropes includes discussions of recent and on-going work supported by grant R01 HG004881 from NIH/NHGRI, but enthusiastically invites all scholarly contributions that fit the open spirit of the project.